# ORI Health Intelligence Platform - Full Context
# https://ori.health
# Last Updated: 2026-02-19
# For AI crawlers and assistants needing comprehensive context

> ORI is the clinical intelligence layer for women's health, built by ORI Health.
> This file provides extended context for AI systems that need deeper understanding
> of our platform's capabilities, data assets, and integration points.

## Platform Overview

ORI (pronounced "or-ee") is a women's health intelligence platform that provides
sex-specific clinical data infrastructure. The platform serves 7 stakeholder groups:
employers, payers/insurers, clinicians, pharma/researchers, financial advisors,
policy makers, and consumers/patients.

The core thesis: women's health is systematically under-researched, under-diagnosed,
and under-funded. ORI quantifies these gaps with verifiable data and provides
actionable tools to close them.

## Frequently Asked Questions

### What is the gender health gap?
The gender health gap refers to systematic differences in healthcare quality, research
funding, and clinical outcomes between men and women. Women wait 4 years longer for
diagnosis on average, receive fewer pain interventions, and are underrepresented in
clinical trials. The McKinsey Global Institute estimates this gap costs the global
economy $1 trillion annually in lost productivity and excess healthcare spending.

### How does ORI quantify the cost of women's health gaps for employers?
ORI's Workforce Impact Simulator calculates the hidden cost of unmanaged women's
health conditions in a workforce. For a typical 1,000-employee company with 52% female
workforce, the model identifies $4.2M/year in combined absenteeism (menstrual disorders:
9 days/year, menopause: 11 days/year), presenteeism (30-40% productivity loss), and
turnover ($52K average replacement cost per departing employee due to menopause).

### What is sex-specific drug dosing and why does it matter?
Most drug doses were established in clinical trials that enrolled predominantly male
participants. Women metabolize many drugs differently due to differences in body
composition (higher fat percentage affects drug distribution), CYP enzyme expression
(CYP3A4 is 20-40% more active in women), renal clearance rates, and hormonal
fluctuations across the menstrual cycle. The FDA mandated a 50% dose reduction of
zolpidem (Ambien) for women in 2013 after decades of data showing women experienced
dangerous next-morning impairment at the standard dose.

### What is a diagnostic odyssey?
A diagnostic odyssey is the prolonged, often years-long journey patients undergo before
receiving a correct diagnosis for conditions like endometriosis (average 7.5 years),
PCOS (average 2-4 years), or autoimmune conditions (average 4.5 years). During this
time, patients accumulate significant costs from repeated specialist visits, unnecessary
tests, misdiagnoses, and ineffective treatments. ORI's Diagnostic Odyssey Decoder maps
these journeys and calculates total cost burden ranging from $15,000 to $100,000+ per patient.

### How does ORI help with reinsurance and actuarial pricing?
ORI's Reinsurance Scenario Modeler helps actuaries incorporate sex-specific risk factors
into reserve calculations. Traditional actuarial models underestimate female-specific
IBNR (Incurred But Not Reported) claims, particularly for conditions with long diagnostic
delays. The model provides reserve adequacy checks, 5-year projection tables, and
quantifies the pricing edge from sex-aware modeling.

### What clinical assessments does ORI support?
ORI administers validated clinical instruments with proper scoring algorithms: PHQ-9
(depression screening with suicide risk flagging), PFDI-20 (pelvic floor distress with
3 subscales: prolapse, colorectal, urinary), GAD-7 (anxiety screening), Rotterdam
criteria (PCOS phenotyping into subtypes A/B/C/D), and custom assessments for menopause
severity and diagnostic pathway triage.

### How does ORI integrate with AI assistants?
ORI runs as an MCP (Model Context Protocol) server. AI assistants like Claude can connect
directly to access 115+ tools. The MCP server provides structured JSON responses with
citations, confidence levels, and appropriate caveats. Integration requires an API key.

### What data sources does ORI use?
ORI aggregates data from: FDA FAERS (18M+ adverse event reports), CMS (PPRRVU 2026
reimbursement schedules), ClinicalTrials.gov (400K+ trials), PubMed/MEDLINE (citation
verification), NHANES (population-level lab ranges), Open Targets (genetic associations),
and BFS Swiss Federal Statistics (pension and labor data). All data sources are cited
in tool outputs.

### How does ORI handle the menstrual cycle in its analysis?
ORI's Cycle Intelligence Engine integrates with Oura Ring and other wearables to provide
phase-aware health interpretation. HRV naturally drops 10-15% in the luteal phase, resting
heart rate increases 2-5 BPM around ovulation, and sleep architecture shifts across the
cycle. ORI contextualizes health data within the current cycle phase (menstrual, follicular,
ovulatory, early luteal, late luteal) to prevent false alarms and identify genuine concerns.

### What is the pension gap from caregiving?
Women perform 75% of unpaid caregiving globally. This reduces workforce participation,
Social Security contributions, and retirement savings. ORI calculates country-specific
pension gaps: in the US, 5 years out of the workforce for caregiving results in approximately
$143,000 in lost lifetime retirement income. In Switzerland, the gap can exceed CHF 200,000
due to the BVG/LPP occupational pension structure.

## Complete Tool Catalog

### Patient/Consumer Tools
- `check_female_dosing` - Sex-specific drug dosing verification
- `analyze_if_hormonal` - Symptom-cycle phase correlation
- `apply_cycle_context` - Contextualize symptoms within cycle day
- `get_cycle_phase` - Determine current cycle phase from last period date
- `log_symptom_with_context` - Track symptoms with hormonal context
- `stratify_phenotype` - PCOS, endometriosis, migraine subtyping
- `predict_autoimmune_flare` - Flare risk from cycle + stress
- `check_injury_risk` - Sport injury risk by cycle phase
- `assess_cardio_risk_from_cycle` - Cardiovascular risk from menstrual patterns
- `interpret_labs_female` - Lab interpretation with female-specific ranges
- `interpret_hrv_female` - HRV interpretation accounting for cycle
- `generate_care_packet` - Pre-appointment preparation documents
- `generate_advocacy_document` - Insurance appeal support

### Clinician Tools
- `lint_missed_revenue` - Find missed billing codes in clinical notes
- `recalibrate_labs_nhanes` - NHANES population reference recalibration
- `query_cms_coverage` - CMS coverage with sex-specific denial patterns
- `lookup_icd10_sex_aware` - ICD-10 with underdiagnosis alerts
- `search_npi_providers` - NPI provider search with women's health enrichment

### Employer/HR Tools
- `calculate_workforce_impact` - Quantify hidden productivity costs
- `generate_cfo_report` - CFO-ready financial impact report
- `calculate_pain_cost` - Individual pain condition economic burden
- `generateFiduciaryPlan` - Fiduciary duty compliance planning (NEW)

### Payer/Insurance Tools
- `detect_failure_demand` - Claims pattern analysis for preventable visits
- `check_network_adequacy` - Ghost network detection in women's health
- `analyzePortfolio` - Diagnostic waste and cost optimization (NEW)

### Pharma/Research Tools
- `query_fda_faers` - FAERS adverse event query with sex filter
- `analyze_drug_interaction` - Pharmacogenomic interaction check
- `triangulate_label_expansion` - Off-label expansion evidence
- `predict_safety_signals` - Post-market safety predictions
- `monitor_competitor_targets` - Competitive pipeline intelligence
- `pkDiscoveryPipeline` - Sex-specific PK difference scanner (NEW)
- `sexBiasAuditEngine` - Trial protocol bias audit (NEW)
- `pharmaTrialIntelligence` - Trial risk and signal scanning (NEW)

### Financial Advisor Tools
- `optimize_hsa_fsa` - Health savings optimization by condition
- `calculate_pension_gap` - Country-specific retirement gap
- `generate_enrollment_recommendation` - Plan selection guidance

### Policy/Government Tools
- `calculate_condition_burden` - National economic burden by condition
- `get_victoria_economic_impact` - Women's health economic impact data

### Swiss Healthcare Tools
- `search_tardoc` - TARDOC billing code search
- `map_tarmed_to_tardoc` - TARMED to TARDOC migration
- `simulate_tardoc_revenue` - Revenue impact from tariff changes
- `audit_eae_compliance` - EAE compliance auditing

### Reinsurance/Actuarial Tools
- `runScenario` - Sex-risk scenario modeling (NEW)
- `calculateReserveAdequacy` - Reserve sufficiency check (NEW)

### Diagnostic Intelligence
- `diagnosticOdysseyDecoder` - Diagnostic journey mapping (NEW)
- `efasSexEquityEngine` - EFAS/TARDOC sex equity analysis (NEW)

## URL Directory

### Primary Pages (High Priority for Indexing)
- https://ori.health/ - Homepage and platform overview
- https://ori.health/workspace/employer - Employer workspace (workforce impact, pension gap, ghost costs)
- https://ori.health/workspace/payer - Payer workspace (claims intelligence, failure demand, cost optimization)
- https://ori.health/workspace/clinician - Clinician workspace (revenue linting, dosing, assessments)
- https://ori.health/workspace/pharma - Pharma/Research workspace (FAERS, trials, phenotypes)
- https://ori.health/workspace/advisor - Financial advisor workspace (HSA/FSA, pension gap)
- https://ori.health/workspace/policy - Policy workspace (national burden, FDI impact)
- https://ori.health/workspace/patient - Consumer workspace (cycle tracking, symptoms, advocacy)
- https://ori.health/evidence - Evidence base and research citations
- https://ori.health/pricing - Platform pricing and access tiers

### Product Tools
- https://ori.health/tools - All clinical tools directory
- https://ori.health/tools/yentl - Yentl Dosing Checker (sex-specific drug doses)
- https://ori.health/tools/cost-of-pain - Pain condition economic burden calculator
- https://ori.health/tools/diagnostic-pathway - Diagnostic pathway navigator
- https://ori.health/tools/diagnostic-delay - Diagnostic delay calculator
- https://ori.health/tools/caregiving - Caregiving value calculator
- https://ori.health/calculators - Calculator hub
- https://ori.health/assessments - Clinical assessment instruments

### Intelligence Dashboards
- https://ori.health/reinsurance - Reinsurance sex-risk dashboard
- https://ori.health/drug-signals - FAERS drug signal explorer
- https://ori.health/mechanisms - Mechanism of action hunter
- https://ori.health/trial-rescue - Clinical trial rescue scanner
- https://ori.health/triangulate - Label expansion triangulation
- https://ori.health/odyssey - Diagnostic odyssey shortener
- https://ori.health/pk-discovery - PK discovery pipeline (NEW)
- https://ori.health/sex-bias-audit - Sex bias audit dashboard (NEW)
- https://ori.health/diagnostic-odyssey - Diagnostic odyssey decoder (NEW)
- https://ori.health/pharma-risk-scanner - Pharma risk scanner (NEW)
- https://ori.health/payers/claims-intelligence - Claims intelligence dashboard
- https://ori.health/pension-calculator - Swiss pension calculator

### Documentation
- https://ori.health/docs/api - API documentation
- https://ori.health/llms.txt - AI context (concise)
- https://ori.health/llms-full.txt - AI context (comprehensive, this file)

## Organizational Information

ORI Health is a research initiative focused on closing the gender health gap through
data infrastructure. The platform is built by the FemTechnology Association.

- Website: https://ori.health
- Newsletter: https://femtechnology.substack.com
- Social: https://linkedin.com/company/femtechnology
- Contact: support@ori.health